Cynogen bromide and ethylacetoacetate in  heterocyclization : Novel synthesis of tetracyclic derivative of 3‐aryl quinazolinones | Zendy

Deshmukh M. B. | Zendy; Patil Suresh S. | Zendy; Patil Sanjeevani S. | Zendy; Jadhav Swati D. | Zendy

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Cynogen bromide and ethylacetoacetate in heterocyclization : Novel synthesis of tetracyclic derivative of 3‐aryl quinazolinones

Author(s) -

Deshmukh M. B.,

Patil Suresh S.,

Patil Sanjeevani S.,

Jadhav Swati D.

Publication year - 2010

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.440

Subject(s) - chemistry , cyanogen bromide , bromide , combinatorial chemistry , aryl , derivative (finance) , proton nmr , tricyclic , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , economics , financial economics , peptide sequence , gene

In this work, tricyclic 1‐amino‐4‐(substituted phenyl)[1,2,4]triazolo[4,3‐ a ]quinazolin‐5(4 H )‐one 3 was synthesized by treatment of 2‐hydrazinyl‐3‐(substituted phenyl)quinazolin‐4(3 H )‐one 2 with cyanogen bromide, which on cyclization with ethylacetoacetate to get the targeted fused tetracyclic derivatives of quinazoli‐4(3H)one 4 . The synthesized compounds have been characterized using IR and 1 H NMR, mass spectral data together with elemental analysis. J. Heterocyclic Chem., (2010).

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