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Cynogen bromide and ethylacetoacetate in heterocyclization : Novel synthesis of tetracyclic derivative of 3‐aryl quinazolinones
Author(s) -
Deshmukh M. B.,
Patil Suresh S.,
Patil Sanjeevani S.,
Jadhav Swati D.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.440
Subject(s) - chemistry , cyanogen bromide , bromide , combinatorial chemistry , aryl , derivative (finance) , proton nmr , tricyclic , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , economics , financial economics , peptide sequence , gene
AbstractIn this work, tricyclic 1‐amino‐4‐(substituted phenyl)[1,2,4]triazolo[4,3‐ a ]quinazolin‐5(4 H )‐one 3 was synthesized by treatment of 2‐hydrazinyl‐3‐(substituted phenyl)quinazolin‐4(3 H )‐one 2 with cyanogen bromide, which on cyclization with ethylacetoacetate to get the targeted fused tetracyclic derivatives of quinazoli‐4(3H)one 4 . The synthesized compounds have been characterized using IR and 1 H NMR, mass spectral data together with elemental analysis. J. Heterocyclic Chem., (2010).