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Synthesis, complexation, and biological activity studies of 4‐aminomethyl‐7,8‐dihydroxy coumarines and their crown ether derivatives
Author(s) -
Gümüş Arzu,
Karadeniz Şeref,
Uğraş Halil İbrahim,
Bulut Mustafa,
Çakır Ümit,
Gören Ahmet Ceyhan
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.435
Subject(s) - chemistry , dichloromethane , crown ether , ether , biological activity , nuclear magnetic resonance spectroscopy , organic chemistry , medicinal chemistry , mass spectrometry , ion , chromatography , solvent , biochemistry , in vitro
The article focuses synthesis of novel 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by 1 H NMR, 13 C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca 2+ , Mg 2+ , Fe 2+ , Zn 2+ , Ni 2+ , Cd 2+ , Co 2+ , and Mn 2+ ions at 25°C ± 0.1 with the 4‐aminomethyl‐7,8‐dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma‐Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity. J. Heterocyclic Chem., (2010).