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Synthesis, biological evaluation, and docking studies of various β‐substituted porphyrin conjugates embedded with N‐containing heterocycles
Author(s) -
Masaret Ghada S.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4314
Subject(s) - chemistry , porphyrin , docking (animal) , combinatorial chemistry , conjugate , stereochemistry , spectral properties , organic chemistry , computational chemistry , medicine , mathematical analysis , nursing , mathematics
A new methodology for the synthesis of some new β‐porphyrin heterocyclic compounds containing nitrogen derivatives 10 , 12 , 13 , 15 , 17 , 19 , 21 , 22 , 25 , 27 , and 29 was screened for their cytotoxic activities. Both elemental and spectral analyses were used to confirm the structures of new compounds. Compounds 22 , 27 , and 21 exhibited very strong activity against the HepG2 cell line. Investigation of the binding between porphyrin 22 and the binding site of telomerase was performed by molecular docking.