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Preparation and evaluation of antibacterial activity of some new 1,2,4‐triazole derivatives
Author(s) -
Arafa W. A. A.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.431
Subject(s) - chemistry , antibacterial activity , 1,2,4 triazole , carbohydrazide , combinatorial chemistry , triazole , nuclear chemistry , organic chemistry , bacteria , genetics , biology
Cyclizations of 1,5‐diphenyl[1,2,4]triazole‐3‐carbohydrazide 1 and the thiosemicarbazide 2 (derived from 1 by addition to phenylisothiocyanate) under various conditions afforded novel biheterocyclic systems. The newly prepared compounds were screened for their antibacterial activity . The results showed that several of these compounds exhibited significant antibacterial activity . J. Heterocyclic Chem., (2010).