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Synthesis of methyl 1, 5‐diaryl‐1 H ‐pyrrole‐2‐carboxylates via acid‐catalyzed ring‐opening/ring‐closure sequence
Author(s) -
Huang Long,
Luo Chenghao,
Xu Panpan,
Liu Bing,
Zhang Duntie,
Zhang Jing,
Pang Denghong,
Gong Yuefa
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4306
Subject(s) - chemistry , pyrrole , ring (chemistry) , catalysis , closure (psychology) , medicinal chemistry , sequence (biology) , organic chemistry , economics , market economy , biochemistry
A facile synthesis of methyl 1,5‐diaryl‐1 H ‐pyrrole‐2‐carboxylates was reported in this article. Acid‐catalyzed reaction of methyl 2‐aroyl‐1‐phenoxycyclopropanecarboxylates with aromatic amines underwent smoothly to give methyl 1,5‐diaryl‐1 H ‐pyrrole‐2‐carboxylates in high to excellent yields under mild conditions.