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Synthesis, cytotoxicity assessment and antioxidant activity of some new thiazol‐2‐yl carboxamides
Author(s) -
Sofan Mamdouh A.,
ElMekabaty Ahmed,
Hasel Ali M.,
Said Samy B.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4301
Subject(s) - chemistry , thiazole , benzothiazole , thiazolidine , antioxidant , pyridine , abts , reagent , pyrazole , imidazopyridine , cytotoxicity , medicinal chemistry , stereochemistry , potassium dichromate , combinatorial chemistry , in vitro , organic chemistry , biochemistry , dpph
Dependence on the biological activity of 2‐aminothiazole, the synthesis and chemical reactions of ethyl 3‐oxo‐3‐(thiazol‐2‐ylamino)propanoate ( 1 ) with some different reagents were described for cytotoxic and antioxidant evaluation. The new derivatives 2–19 could be synthesized and characterized by correct analytical and spectral data. In addition to the thiazole ring, these compounds contain 2 H ‐1,2,3‐triazole ( 3 ), 1 H ‐pyrazole ( 5 , 12 ), 1,3‐dithiane ( 7 ), benzothiazole ( 10 ), thiazolidine ( 13 ), thiazolidinone ( 14 , 15 ), 2 H ‐chromene ( 17 ), pyridine ( 19 ) moieties. The preparation of compounds 2–19 was performed through the formation of the isolable 2‐(2‐phenylhydrazineylidene) 2 , 2‐dimethylaminomethylidene 4 , 2‐phenylcarbamothioyl 9 , 2‐(methylthio)(phenylamino) methylidene 11 and non‐isolable potassium bis(thiolate) 6 , potassium thiolate 8 intermediates from precursor 1 . The activity of these derivatives 1–19 against human lung fibroblast (WI38) and human prostate cancer (PC3) were examined in vitro using the MTT assay. The assessment of their antioxidant activities was carried out by following the ABTS method to evaluate their pharmaceutical importance.