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Synthesis of julolidines via one‐pot cascade three component Povarov reaction in the presence of silica sulfuric acid
Author(s) -
Kaboudin Babak,
Sohrabi Masoumeh,
Kazemi Foad
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4283
Subject(s) - chemistry , aniline , catalysis , sulfuric acid , styrene , organic chemistry , formaldehyde , cycloaddition , imine , cascade reaction , cascade , polymer chemistry , copolymer , chromatography , polymer
In this report, synthesis of julolidines via one‐pot cascade reaction of aniline derivatives with a mixture of styrene and formaldehyde in the presence of silica sulfuric acid as an efficient catalyst has been studied under aerobic condition. By presented method, various julolidines are obtained under mild and transition metal‐free conditions. The reaction is proceeded with imine formation and followed by an Aza‐Diels‐Alder cycloaddition with styrene gave julolidine derivatives. The catalyst can be recycled and reused multiple times to catalyze the reaction.