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Synthesis and characterization of potential impurities of Oxcarbazepine drug substance: An antiepileptic agent
Author(s) -
Velugula Siva Rama Kasibabu,
Reddy Aaramadaka Sunil Kumar,
Misra Nimesh Chandra,
Reddy Pindi Santhosh,
Chavakula Ramadas,
Guduri Anil Kumar,
Douglas Sanasi Paul
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4281
Subject(s) - oxcarbazepine , chemistry , impurity , drug , antiepileptic drug , epilepsy , pharmacology , organic chemistry , carbamazepine , medicine , psychology , neuroscience
Oxcarbazepine is a drug substance used to treat epilepsy. During its bulk synthesis of various impurities formation will be observed. Herein we describe the formation, synthesis and characterization of four potential impurities, namely, N ‐acetyl Oxcarbazepine, N ‐formyl Oxcarbazepine, N ‐carbamoyl Oxcarbazepine, and Oxcarbazepine dimer. These impurities are listed in several Pharmacopoeias and the control of these impurities below the threshold level is essential. Our study will be a guide for making these reference standards.