Synthesis and characterization of potential impurities of Oxcarbazepine drug substance: An antiepileptic agent | Zendy

Velugula Siva Rama Kasibabu | Zendy; Reddy Aaramadaka Sunil Kumar | Zendy; Misra Nimesh Chandra | Zendy; Reddy Pindi Santhosh | Zendy; Chavakula Ramadas | Zendy; Guduri Anil Kumar | Zendy; Douglas Sanasi Paul | Zendy

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Synthesis and characterization of potential impurities of Oxcarbazepine drug substance: An antiepileptic agent

Author(s) -

Velugula Siva Rama Kasibabu,

Reddy Aaramadaka Sunil Kumar,

Misra Nimesh Chandra,

Reddy Pindi Santhosh,

Chavakula Ramadas,

Guduri Anil Kumar,

Douglas Sanasi Paul

Publication year - 2021

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.4281

Subject(s) - oxcarbazepine , chemistry , impurity , drug , antiepileptic drug , epilepsy , pharmacology , organic chemistry , carbamazepine , medicine , psychology , neuroscience

Oxcarbazepine is a drug substance used to treat epilepsy. During its bulk synthesis of various impurities formation will be observed. Herein we describe the formation, synthesis and characterization of four potential impurities, namely, N ‐acetyl Oxcarbazepine, N ‐formyl Oxcarbazepine, N ‐carbamoyl Oxcarbazepine, and Oxcarbazepine dimer. These impurities are listed in several Pharmacopoeias and the control of these impurities below the threshold level is essential. Our study will be a guide for making these reference standards.

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