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Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives
Author(s) -
Moghaddammanesh Mohammadreza,
Beyzaei Hamid,
Heidari Majd Mostafa,
Hosseinzadegan Sara,
Ghazvini Kiarash
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4278
Subject(s) - chemistry , thiazole , dpph , antioxidant , antimicrobial , minimum inhibitory concentration , minimum bactericidal concentration , antifungal , cytotoxicity , antibacterial activity , mtt assay , viability assay , combinatorial chemistry , organic chemistry , microbiology and biotechnology , biochemistry , bacteria , in vitro , biology , genetics
In this study, anticancer, antibacterial (against hospital‐isolated antibiotic‐resistant Escherichia coli strains), antifungal, and antioxidant effects of synthesized heterocyclic compounds 5 and 7 containing thiazole core were examined. Cytotoxicity testing was utilized against MCF‐7 breast cancer cells via MTT cell viability assay. Antibacterial and antifungal activities were checked out according to Clinical and Laboratory Standards Institute (CLSI) guidelines, and antioxidant properties were evaluated through scavenging 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radicals. Results showed the viability of breast cancer cell lines was reliant on concentration of heterocycles and time of incubation. Synthetic compounds exhibited excellent antibacterial and antifungal properties base on their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values as well as high antioxidant activities according to their IC 50 values. Higher anticancer and antibacterial properties were observed with compound 7; on the contrary, thiazole 5 had better antioxidant effects. They can be introduced as potent antimicrobial, antioxidant, and anticancer agents.