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Metal‐free multicomponent synthesis and in vitro antioxidant activity of indolylpyrazolopyrimidines
Author(s) -
Nadiveedhi Maheshwara Reddy,
Shaik Mahammad Sadik,
Krishnammagari Suresh Kumar,
Cirandur Suresh Reddy
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4273
Subject(s) - chemistry , aldehyde , ketone , antioxidant , ascorbic acid , in vitro , organic chemistry , combinatorial chemistry , biochemistry , catalysis , food science
Abstract Multisubstituted indolylpyrazolopyrimidines were synthesized in good yields with base promoted one‐pot multicomponent system from aldehyde, ketone, and indolylpyrazolamine. Milder and cost‐effective conditions are the highlights of the present protocol. Among the synthesized compounds ( 4a‐j ) 4b , 4c , 4e , and 4f have shown significant better in vitro antioxidant activity compared to standard ascorbic acid.