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Catalyst free synthesis of 2‐Aryl‐2 H ‐benzo[ b ][1,4]oxazines and 3‐Aryl‐2H ‐benzo[ b ][1,4]thiazin‐2‐ones: An ultrasonication‐assisted strategy
Author(s) -
Teli Bisma,
Waseem Malik Abdul,
Rashid Showkat,
Ganaie Bilal Ahmad,
Bhat Bilal A.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4267
Subject(s) - chemistry , oxazines , aryl , catalysis , phenacyl , adduct , medicinal chemistry , combinatorial chemistry , organic chemistry , alkyl
An ultrasonication‐assisted synthesis of 2‐Aryl‐2 H ‐benzo[ b ][1,4]oxazines and 3‐aryl‐2 H ‐benzo[ b ][1,4]thiazin‐2‐ones has been established by reacting phenacyl bromides with 2‐aminophenol and 2‐aminothiophenol, respectively. This approach fosters flexibility in generating a diverse range of 1,4‐benzoxazines and 1,4‐benzothiazinones under catalyst‐free reaction conditions. Further scope toward the synthesis of rarely occurring bis ‐benzoxazine adduct has also been explored, which enabled us to propose the reaction mechanism.