Premium
Synthesis and structural study of N ‐methyl‐2‐methylthiopyrimidine derivatives from trihalomethylated enones
Author(s) -
Zanatta Nilo,
Madruga Claudia C.,
Marisco Patricia C.,
da Rosa Luciana S.,
da Silva Fabio M.,
Bonacorso Helio G.,
Martins Marcos A. P.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.425
Subject(s) - chemistry , chemoselectivity , steric effects , sulfate , electronic effect , medicinal chemistry , stereochemistry , organic chemistry , catalysis
AbstractThe synthesis and chemoselective study of a novel series N ‐methyl‐2‐methylthio‐tetrahydropyrimidines and or N ‐methyl‐2‐methylthiodihydropyrimidines, from the cyclocondensation reaction of β‐alkoxyvinyl trihalomethyl ketones (enones) with 1,2‐dimethylisothiourea sulfate is described. It was found that the chemoselectivity depends on both the reaction conditions and the steric and electronic effects of the substituents on the enones. J. Heterocyclic Chem., (2010).