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Synthesis and molecular docking of some new 3,5‐bis‐(diazipine, pyrazolopyrimidine, pyrimidine, and pyrazole) pyridine derivatives and their in vitro and in vivo biological evaluation as potential antitumor agents
Author(s) -
Soliman Nanees N.,
Tag Yasmin M.,
Bayoumy Nesma M.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4244
Subject(s) - chemistry , pyrazole , pyrimidine , in vitro , in vivo , docking (animal) , combinatorial chemistry , pyridine , stereochemistry , biochemistry , organic chemistry , medicine , microbiology and biotechnology , nursing , biology
Abstract Bis enaminone derivative 6 was reactive enaminone to synthesize new heterocyclic compounds containing diazipine, pyrazolopyrimidine, triazolopyrimidine, and pyrazole moieties by reaction with different bifunctional reagents. Structures of new compounds were confirmed by analytical and spectral data. Moreover, the new compounds were screened in‐vitro as antitumor agents for Ehrlich ascites at different concentration. The results showed the compounds 18 , 19, and 20a have a good activity. In addition to, the molecular docking of these mentioned compounds was studied using vascular endothelial growth factor receptor.