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Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus ( H 5 N 8 )
Author(s) -
ElHelw Eman A. E.,
Morsy Alaa R. I.,
Hashem Ahmed I.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4233
Subject(s) - chemistry , synthon , moiety , chloroacetyl chloride , hydrazide , acetic anhydride , furan , chloride , combinatorial chemistry , organic chemistry , catalysis
The hydrazide obtained from furan‐2(3 H )‐one integrated with a quinolin‐2(1 H )‐one core reported previously by our research group was utilized as a building block synthon to obtain some pyrrolone, pyridazinone, oxadiazole, and triazole derivatives through treating with some carbon electrophilic reagents, for example, chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, 3,4‐dimethoxybenzaldehyde, and 2‐oxoquinolin‐3‐carbaldehyde to achieve the target heterocycles. The newly synthesized compounds were evaluated as immunomodulator against highly pathogenic avian influenza virus (H 5 N 8 ). The compounds 1 , 11 , and 17 displayed the highest potency (100% protection).