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Catalyst‐free facile and efficient one‐pot synthesis of densely functionalized pyrroles and α‐amino ketones
Author(s) -
Vanga Sivarama Krishna Reddy,
Bollikolla Hari Babu,
Peruri V. V. Satyanarayana
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4227
Subject(s) - chemistry , catalysis , organic chemistry , column chromatography , combinatorial chemistry , one pot synthesis
An efficient catalyst‐free one‐pot three‐component synthesis of penta‐substituted pyrroles has been successfully developed. A variety of penta‐substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily accessible starting materials under mild conditions. This protocol also provided α ‐amino ketones in good yields (87%–98%) without column chromatography.