Premium
A straightforward route to alkyl 5‐arylthiophene ‐2‐thiocarboxylates from alkyl 2‐aroyl ‐1‐chlorocyclopropanecarboxylates
Author(s) -
Huang Long,
Liu Xuehui,
Zhang Duntie,
Luo Chenghao,
Zhang Jing,
Chen Yikun,
Gong Yuefa
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4225
Subject(s) - alkyl , chemistry , reagent , cyclopropane , ring (chemistry) , cycloisomerization , medicinal chemistry , organic chemistry , catalysis
In this article, a direct synthetic method for alkyl 5‐arylthiophene‐2‐thiocarboxylates was reported. Treatment of alkyl 2‐aroyl‐1‐chlorocyclopropanecarboxylates with excess amount of Lawesson's reagent readily afforded alkyl 5‐arylthiophene‐2‐thiocarboxylates in good to excellent yields under mild conditions. This cycloisomerization reaction process would be initiated by a ring‐opening of the strained cyclopropane.