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Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)‐Ambrisentan
Author(s) -
Madhu Madasu,
Doda Sai Reddy,
Begari Prem Kumar,
Dasari Krishna Rao,
Thalari Gangadhar,
Kadari Sudhakar,
Yadav Jhillu Singh
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4223
Subject(s) - enantioselective synthesis , chemistry , epoxide , chiral auxiliary , hydrolysis , regioselectivity , organic chemistry , total synthesis , combinatorial chemistry , catalysis
Enantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions are the key reactions.

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