Synthesis of new metal‐free 1,2,4,5,9,10,12, 13‐octaaza [16]annulene derivatives using the reaction of vinamidinium salts with thiocarbohydrazide

A new series of marcocyclic ligands, 1,2,4,5,9,10,12,13‐octaaza[16]annulene derivatives were synthesized by using the condensation reaction of the correspondingly [2+2] 2‐heteroaryl‐substituted vinamidinium salts or phenyl vinamidinium salts and derivatives or halo‐substituted vinamidinum salt [1A‐10A] with thiocarbohydrazide in ethanolic medium under mild condition. Metal complexes were formed by reacting of ethanolic solution of Co, Ni, and Zn with macrocyclic ligand in ethanolic medium under mild condition. Purposed complexes have been characterized with the help of elemental analyses, comparative absorption band of ν(C=N), mass, and NMR. Geometry and complex formulation are out of scope of this work. The biological activities of carohydrazide and thiocarbohydrazide base of the ligands and purposed complexes such as antimicrobial, antitumor, and insecticides have attracted significant attention in bioorganic chemistry.