Premium
Concise synthesis of chiral pyrazolo[4,3‐ f ] [1,4]oxazepines and pyrazolo[4,3‐ f ] [1,4]thiazepines bearing pyrazole unit
Author(s) -
Pitchai Manivel,
Ulaganathan Sankar,
Venkateshappa Suresh Shagathur,
Akunuri Arun,
Rampulla Richard,
Mathur Arvind,
Gupta Anuradha
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4195
Subject(s) - chemistry , pyrazole , imine , stereochemistry , intramolecular force , aryl , combinatorial chemistry , alkyl , organic chemistry , catalysis
An efficient synthesis of pyrazolo [1,4]‐oxazepines and [1,4]‐thiazepines bearing a variety of alkyl and aryl groups with a chiral center has been developed. The synthesis started with readily available 5‐chloro‐pyrazole‐4‐carbaldehyde and chiral amino alcohols. The key step involves intramolecular imine formation. These classes of compounds are potentially useful as templates for drug discovery.