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Facile synthesis of 2,4‐diamino‐6‐alkyl‐ or 6‐aryl‐pyrimidine derivatives
Author(s) -
Wang Xihong,
Sathunuru Ramadas,
Melendez Victor,
Kozar Michael P.,
Lin Ai J.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.419
Subject(s) - chemistry , amidine , pyrimidine , alkyl , guanidine , aryl , ring (chemistry) , derivative (finance) , coupling reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , financial economics , economics
Facile methods were developed to prepare a series of 6‐phenyl and 6‐alkyl‐2,4‐diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3‐dicarbonyl derivative with an amidine or guanidine. The 6‐phenyl‐pyrimidine derivatives were also prepared by Suzuki coupling reaction , using 2‐methylthio‐4,6‐dichloropyrimidine as the starting material. J. Heterocyclic Chem., (2010).
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