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AgI ‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water
Author(s) -
Guguloth Veeranna,
Balaboina Ramesh,
Paidakula Suresh,
Thirukovela Narasimha S.,
Vadde Ravinder
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4184
Subject(s) - chemistry , intramolecular force , pyridine , substrate (aquarium) , combinatorial chemistry , grignard reagent , grignard reaction , mannich reaction , medicinal chemistry , catalysis , organic chemistry , stereochemistry , reagent , oceanography , geology
The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.