Premium
Green synthesis of 1,3,4‐oxadiazole derivatives based on N ‐arylidene‐2‐(1‐oxo‐4‐(4‐phenoxyphenyl)phthalazin‐2( 1 H )‐yl)acetohydrazide as potential antitumor agents
Author(s) -
Behalo Mohamed S.,
El Said Ebtsam S.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4181
Subject(s) - chemistry , dichloromethane , ammonium nitrate , cerium , aldehyde , catalysis , oxadiazole , yield (engineering) , medicinal chemistry , organic chemistry , materials science , solvent , metallurgy
Design of a new series of 1,3,4‐oxadiazole derivatives was achieved in good yield via treatment of N ‐arylidene‐2‐(1‐oxo‐4‐(4‐phenoxyphenyl)phthalazin‐2(1 H )‐yl)acetohydrazide with cerium (IV) ammonium nitrate as a catalyst. They can be formulated also using one‐pot reaction of 2‐(1‐oxo‐4‐(4‐phenoxyphenyl)phthalazin‐2(1 H )‐yl)acetohydrazide, aromatic aldehyde and cerium (IV) ammonium nitrate in dichloromethane. The structural formulas of all synthesized products were elucidated based on their elemental and spectral analyses. In addition, MTT assay was used to evaluate antitumor activity of the synthesized molecules and some of them showed potent activity in comparison with Doxorubicin as a standard drug.