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Synthesis of bis(1,5‐disubstituted tetrazoles) via double four component Azido‐Ugi reaction
Author(s) -
Dehghan Negin,
NasrIsfahani Hossein,
Sarvary Afshin,
Bakherad Mohammad
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4178
Subject(s) - chemistry , isocyanide , tetrazole , aldehyde , ugi reaction , amine gas treating , reagent , component (thermodynamics) , mass spectrum , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , physics , thermodynamics , ion
A double four component Azido‐Ugi reaction of isocyanide, TMSN 3 , aldehyde, and 4,4′‐sulfonyldianiline with two amine functional groups in MeOH at 65°C has been described. The synthesis of pharmacologically and structurally interesting compounds with two 1,5‐disubstituted tetrazole rings via a reaction from available and inexpensive reagents under a convenient process and mild reaction conditions has been reported. Modifications in the structure of the reaction product could be followed by varying the aldehyde or isocyanide component. The products are new and were well described by Mass, 1 H NMR, and 13 C NMR spectral studies.