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Synthesis, antimicrobial, and mitotic toxicity evaluation of new 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐ c ]quinazolin‐5( 6 H )‐yl)acetic acids
Author(s) -
Kravtsov Dmytro V.,
Voskoboinik Oleksii Yu.,
Kovalenko Serhii I.
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4161
Subject(s) - chemistry , acetic acid , antimicrobial , stereochemistry , candida albicans , allium , mitotic index , heteronuclear single quantum coherence spectroscopy , proton nmr , two dimensional nuclear magnetic resonance spectroscopy , mitosis , organic chemistry , microbiology and biotechnology , botany , biology
A series of novel 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐ c ]quinazolin‐5(6 H )‐yl)acetic acids were synthesized and characterized by 1 H, 13 C, 19 F NMR, 1 H‐ 1 H‐COSY, 1 H‐ 13 C‐HSQC, NOESY, LC‐MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2‐(6‐(pentafluorophenyl)benzo[4,5]imidazo[1,2‐ c ]quinazolin‐5(6 H )‐yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells of Allium cepa l . roots. In a preliminary antimicrobial evaluation, only Streptococcus pyogenes and Candida albicans were slightly susceptible to some of the synthesized compounds.