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A concise route towards isoflavans
Author(s) -
Basuli Suchand,
Chinnabattigalla Sreenivasulu,
Gupta Kshitija,
Gedu Satyanarayana
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4158
Subject(s) - chemistry , intramolecular force , intermolecular force , combinatorial chemistry , catalysis , key (lock) , nanotechnology , stereochemistry , organic chemistry , molecule , computer science , materials science , computer security
Isoflavans have gained considerable interest owing to their potential health benefits. Herein, we have presented a straightforward strategy for isoflavans synthesis. The strategy features an intermolecular [Cu]‐catalyzed arylation of malonates and an intramolecular [Pd]‐catalyzed Buchwald coupling of hydroxy tethered bromoarenes as the key transformations. This protocol enabled the synthesis of a variety of isoflavan analogs.

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