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A novel eco‐friendly on‐water protocol for the synthesis of 2,2‐disubstituted 2, 3‐dihydro‐1 H ‐perimidines
Author(s) -
Harry Nissy Ann,
Shilpa Thomas,
Ujwaldev Sankuviruthiyil M.,
Anilkumar Gopinathan
Publication year - 2021
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4146
Subject(s) - chemistry , catalysis , combinatorial chemistry , environmentally friendly , organic chemistry , medicinal chemistry , biology , ecology
An efficient green on‐water protocol for the synthesis of 2,2‐disubstituted 2,3‐dihydro‐1 H ‐perimidines is demonstrated. The reaction used safer p ‐toluenesulfonic acid (PTSA) as a catalyst on water at 80°C, for 2 hours affording a novel method for the synthesis of various disubstituted perimidines in moderate to excellent yields.