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Convenient synthesis of novel pyrimido[4,5‐ b ][1,5]benzothiazepines
Author(s) -
Nikpour Mohsen,
Hasanzadeh Neda
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4141
Subject(s) - chemistry , pyrimidine , acetonitrile , benzene , chloroform , boiling , proton nmr , mass spectrum , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , ion
Reaction of 4,6‐dichloropyrimidine‐5‐carbaldehyde with amines in chloroform gave 4‐(substitutedamino)‐6‐chloro‐pyrimidine‐5‐carbaldehydes derivatives at low temperature. Treatment of the latter products with 2‐aminobenzenethiol in alkaline benzene and then in boiling acetonitrile gave a novel group of 11H‐pyrimido[4,5‐ b ][1,5]benzodiazepine derivatives. Structures of the products confirmed by 1 HNMR, IR, and mass spectra.