Premium
Ionic liquid promoted green synthesis of new pyridazino benzazepine derivatives: Evaluation of antioxidant activity
Author(s) -
Dehbandi Behnam,
Hossaini Zinatossadat,
Mirjafari Zohreh,
Zardoost Mohammad Reza
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4127
Subject(s) - chemistry , benzazepine , hydrazine (antidepressant) , benzazepines , ionic liquid , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , chromatography
In this research, we investigated preparation of pyridazino benzazepine derivatives in high yields via the domino and one‐pot reaction of isatoic anhydride, N ‐methylimidazole, alkyl bromides, activated acetylenic compounds, and hydrazine in ionic liquid as green media at 80°C. Also, antioxidation property of some prepared pyridazino benzazepines due to having pyridazin and benzazepine core is investigated by employing of trapping diphenyl‐picrylhydrazine radical and ability of ferric reduction experiment. Our procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency, and simple separation of product from mixture of reaction.