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Synthesis of 3, 4‐dihydropyrimidin ‐2( 1 H )‐one via Retro‐Biginelli reaction
Author(s) -
Mondal Sudipta,
Mondal Mohabul A.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4124
Subject(s) - chemistry , biginelli reaction , scope (computer science) , hydrolysis , organic chemistry , catalysis , computer science , programming language
Hydrolytic behavior of 5‐acetyl‐6‐methyl‐4‐phenyl‐3,4‐dihydropyrimidin‐2(1H)‐one under alkaline condition has been explored. Mechanistic details are established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeds through the retro‐Biginelli reaction. The scope of the retro‐Biginelli reaction has been explored by the synthesis of substituted DHPs.