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Synthesis and antimicrobial agents of thiazolidinone derivatives from benzocyclohepetenone
Author(s) -
Jilla Lavanya,
Kolluri Prashanth Kumar,
Bujji Sushmitha,
Naikal Subhashini
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4117
Subject(s) - chemistry , antimicrobial , propanoic acid , benzotriazole , proton nmr , carbon 13 nmr , amine gas treating , mass spectrum , antibacterial activity , organic chemistry , stereochemistry , hydrochloride , medicinal chemistry , bacteria , ion , biology , genetics
A series of benzosuberone coupled piperazin‐1‐yl thiazolidin‐4‐one derivatives 6a‐j were synthesized from 3‐(2‐[9‐chloro‐2,3‐dimethyl‐6,7‐dihydro‐5 H ‐benzo[7]annulen‐8‐yl]‐4‐oxothiazolidin‐3‐yl)propanoic acid ( 4 ) and substituted piperazines/secondary amines 5a‐j using 1‐hydroxy benzotriazole, 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and triethyl amine in good yields and their structures were characterized by 1 H NMR, 13 C NMR, IR, and Mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity against bacterial strains and a fungal strain. Compounds 6f and 6g were indicated promising and broad spectrum antibacterial activity.