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Synthesis of novel thiazol‐5‐ylpyrimidine derivatives and their antimicrobial evaluation
Author(s) -
Deshmukh Sanjay U.,
Toche Raghunath B.,
Takate Sushama J.,
Salve Supriya P.,
Sabnis Ram W.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4116
Subject(s) - chemistry , fusarium oxysporum , aspergillus flavus , antimicrobial , bacillus subtilis , staphylococcus aureus , bacteria , gram positive bacteria , gram , microbiology and biotechnology , fusarium , escherichia coli , gram negative bacteria , organic chemistry , food science , biochemistry , biology , botany , genetics , gene
Novel thiazol‐5‐ylpyrimidine derivatives were designed and synthesized. The chemical structures of all new synthesized compounds were assigned by studying their elemental analyses and spectral data (FT‐IR, 1 HNMR, 13 C NMR, and MS). The target compounds, 8 and 9a‐9d were evaluated for their antimicrobial activity in vitro against gram‐positive bacteria, Bacillus subtilis and Staphylococcus aureus , gram‐negative bacteria, Salmonella abony and Escherichia coli and fungi, Aspergillus flavus and Fusarium oxysporum . In particular, compounds 9a‐9c exhibited moderate to good activity against gram‐positive bacteria, S. aureus , gram‐negative bacteria, S. abony and fungus, Fusarium oxysporum in comparison with reference drugs.