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Green production and antioxidant activity study of new pyrrolo[2,1‐a]isoquinolines
Author(s) -
Soleimani Amiri Somayeh
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4115
Subject(s) - chemistry , isoquinoline , catalysis , clinoptilolite , organic chemistry , solvent , reagent , medicinal chemistry , zeolite
Abstract In current research, pyrrolo[2,1‐a]isoquinoline derivative are synthesized via a new process of four component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent‐free conditions at room temperature. Also, Dielz‐Alder reactions take place in the reaction of synthesized pyrrolo[2,1‐a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent‐free conditions at room temperature. As well, antioxidation property of some prepared pyrrolo[2,1‐a]isoquinolines are investigated by employing of trapping diphenyl‐picrylhydrazine (DPPH) radical and ability of ferric reduction experiment. Among investigated compounds, compounds 5c have good results relative to BHT and TBHQ as standard antioxidant. Our procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.