An efficient synthesis of 6‐benzyl‐2‐arylthieno[2,3‐ d ]pyrimidin‐4( 3 H  )‐ones catalyzed by  HCl  involving a  Friedel‐Crafts  alkylation reaction | Zendy

Pan WanChen | Zendy; Wang YiChun | Zendy; Li TuanJie | Zendy; Liu JianQuan | Zendy; Wang XiangShan | Zendy

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An efficient synthesis of 6‐benzyl‐2‐arylthieno[2,3‐ d ]pyrimidin‐4( 3 H )‐ones catalyzed by HCl involving a Friedel‐Crafts alkylation reaction

Author(s) -

Pan WanChen,

Wang YiChun,

Li TuanJie,

Liu JianQuan,

Wang XiangShan

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.4107

Subject(s) - chemistry , alkylation , friedel–crafts reaction , thiophene , moiety , catalysis , aldehyde , pyrimidine , ring (chemistry) , condensation , medicinal chemistry , organic chemistry , stereochemistry , physics , thermodynamics

Aldehyde could undergo not only the subsequent condensation and cyclization with 2‐aminothiophene‐3‐carboxamide to build a pyrimidine ring, but also a Friedel‐Crafts alkylation reaction with thiophene moiety to give unexpected 6‐benzyl‐2‐arylthieno[2,3‐ d ]pyrimidin‐4(3 H )‐ ones in good yields catalyzed by concentrated HCl.

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