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An efficient synthesis of 6‐benzyl‐2‐arylthieno[2,3‐ d ]pyrimidin‐4( 3 H )‐ones catalyzed by HCl involving a Friedel‐Crafts alkylation reaction
Author(s) -
Pan WanChen,
Wang YiChun,
Li TuanJie,
Liu JianQuan,
Wang XiangShan
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4107
Subject(s) - chemistry , alkylation , friedel–crafts reaction , thiophene , moiety , catalysis , aldehyde , pyrimidine , ring (chemistry) , condensation , medicinal chemistry , organic chemistry , stereochemistry , physics , thermodynamics
Aldehyde could undergo not only the subsequent condensation and cyclization with 2‐aminothiophene‐3‐carboxamide to build a pyrimidine ring, but also a Friedel‐Crafts alkylation reaction with thiophene moiety to give unexpected 6‐benzyl‐2‐arylthieno[2,3‐ d ]pyrimidin‐4(3 H )‐ ones in good yields catalyzed by concentrated HCl.