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Synthesis and antimicrobial activity of 2‐(4‐(benzo[d]thiazol‐5‐ylsulfonyl)piperazine‐1‐yl)‐N‐substituted acetamide derivatives
Author(s) -
Shinde Ravindra R.,
Gaikwad Dattatray,
Farooqui Mazahar
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4099
Subject(s) - chemistry , acetamide , antimicrobial , candida albicans , aspergillus fumigatus , bacillus subtilis , ciprofloxacin , thiazole , piperazine , clotrimazole , staphylococcus aureus , stereochemistry , microbiology and biotechnology , organic chemistry , bacteria , antibiotics , antifungal , biochemistry , biology , genetics
A new series of 2‐(4‐(benzo[d]thiazol‐5‐ylsulfonyl)piperazin‐1‐yl)‐N‐substituted acetamide (5a‐5k) compounds have been synthesized, and these compounds were characterized with spectral data like IR, NMR, and Mass spectroscopy. All compounds were evaluated in vitro for their efficacy as antimicrobial against Gram‐positive and Gram‐negative pathogenic bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa using ciprofloxacin as a standard and fungal strains like Candida albicans and Aspergillus fumigatus as compared with standard drug Clotrimazole, and Molecular docking study shows that all these compounds were having good to excellent correlation binding energy as compared with binding energy of standard drugs.