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Synthesis of novel spiro‐fused pyrazolo[4′,3′:5,6]pyrido[2,3‐ d ]pyrimidines
Author(s) -
Fazlelahi Hadi Z.,
Moghadam Peyman N.,
Baradarani Mehdi M.,
Joule John A.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4087
Subject(s) - chemistry , barbituric acid , quinoline , oxindole , pyrazole , amine gas treating , component (thermodynamics) , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics , catalysis
New pyrazolo[4′,3′:5,6]pyrido[2,3‐ d ]pyrimidines, with an associated spiro‐3,3′‐oxindole attachment, were prepared by three‐component combinations of 5,6‐dihydro‐4 H ‐pyrrolo[3,2,1‐ ij ]quinoline‐1,2‐dione with a pair of reactants chosen from a pyrazol‐5‐one, a pyrazole‐5‐amine, a barbituric acid, or a 6‐aminouracil.