Premium
ZnO / Fe 3 O 4 nanoparticles promoted green synthesis of pyrazolo pyrimidinones: Study of antioxidant activity
Author(s) -
Ghoorchibeigi Mona,
Larijani Kambiz,
Azar Parviz A.,
Zare Karim,
Mehregan Iraj
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4080
Subject(s) - chemistry , catalysis , dpph , ferric , isocyanate , hydrazine (antidepressant) , yield (engineering) , antioxidant , nuclear chemistry , nanoparticle , organic chemistry , chemical engineering , chromatography , materials science , engineering , metallurgy , polyurethane
The preparation of pyrazolo pyrimidinone derivatives was performed by using five component reactions of phthalaldehyde, cyanomethylamine, electron deficient acetylenic compounds, isocyanate, hydrazine, and catalytic amounts of ZnO/Fe 3 O 4 ‐magnetic nanoparticles as a high performance catalyst under ultrasonic conditions at ambient temperature in aquause media at room temperature. It should be mentioned that this catalyst was prepared using Spinacia oleracea water extract. In addition, for investigation of antioxidant ability, radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media, and easy separation of product and catalyst.