Synthesis of indolo[2,1‐ a ]isoquinolines by  CF 3 COOH ‐induced cyclization | Zendy

Wada Yasuhiro | Zendy; Kurono Nobuhito | Zendy; Senboku Hisanori | Zendy; Orito Kazuhiko | Zendy

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Synthesis of indolo[2,1‐ a ]isoquinolines by CF 3 COOH ‐induced cyclization

Author(s) -

Wada Yasuhiro,

Kurono Nobuhito,

Senboku Hisanori,

Orito Kazuhiko

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.4078

Subject(s) - isoquinoline , chemistry , trifluoroacetic acid , indole test , intramolecular force , stereochemistry , medicinal chemistry , organic chemistry

Indolo[2,1‐ a ]isoquinoline alkaloids and related compounds have been known to have interesting biological activities, such as antileukemic and antitumor activities. We found that 1‐(3,4‐dimethoxyphenethyl)indole gave 2,3‐dimethoxyindolo[2,1‐ a ]isoquinoline and 1‐(3,4‐dimethoxyphenylacetyl)indole gave 2,3‐dimethoxy‐6‐oxoindolo[2,1‐ a ]isoquinoline, respectively, by an intramolecular cyclization carried out in boiling trifluoroacetic acid.

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