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Design and synthesis of new series of 3‐cyanopyridine and pyrazolopyridine derivatives
Author(s) -
Keshk Reda Mohammed
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4058
Subject(s) - chemistry , yield (engineering) , potassium carbonate , pyridine , ethyl chloroacetate , ethyl acetate , elemental analysis , medicinal chemistry , proton nmr , potassium , organic chemistry , mass spectrum , hydrate , ion , materials science , metallurgy
Reaction of 3‐cyano‐4,6‐dimethyl‐2‐pyridone with ethyl chloroacetate afforded ethyl 2‐([3‐cyano‐4,6‐dimethylpyridin‐2‐yl]oxy)acetate 2 and ethyl 2‐(3‐cyano‐4,6‐dimethyl‐2‐oxopyridin‐1[2 H ]‐yl)acetate 3 , the reaction product yield depend on the reaction condition (potassium carbonate concentration and reaction time). These compounds used as precursors to synthesize pyridine derivatives 4 , 6‐10 , 15, 17‐20 , furopyridines 5, 16 , pyrazolopyridine 12 , pyridopyrazolopyrimidines 14a,b . The structure of the newly synthesized compounds was confirmed by spectral data (IR, NMR, and mass spectra) and elemental analysis.