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DABCO mediated one pot synthesis of 2‐(3‐benzyl‐2, 6‐dioxo‐3, 6‐dihydropyrimidin‐1[ 2 H ]‐yl)‐ N ‐(4‐(1, 3‐dioxo‐1 H ‐benzo [ de ]isoquinolin‐2[ 3 H ]‐yl) aryl) acetamides as antimicrobial agents
Author(s) -
Sirgamalla Rambabu,
Adem Kurumanna,
Boda Sakram,
Kommakula Ashok,
Neradi Suryam,
Perka Shyam,
Bojja Kiran,
Arifuddin Mohammed
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4055
Subject(s) - chemistry , dabco , amide , stereochemistry , proton nmr , aryl , active compound , combinatorial chemistry , organic chemistry , octane , alkyl
We report herein DABCO mediated one pot synthesis of 2‐(3‐benzyl‐2 , 6‐dioxo‐3 , 6‐dihydropyrimidin‐1[2H]‐yl)‐N‐(4‐(1 , 3‐dioxo‐1H‐benzo[de]isoquinolin‐2[3H]‐yl) aryl) acetamides ( 4a‐j ) . The silent features of this new one pot synthesis include the shorter reaction time, high yields, simple workup, and simultaneous formation of N ‐Amide and N ‐benzyl bonds in the one pot. The newly synthesized compounds ( 4a‐j ) were characterized by different spectral techniques such as IR, 1 H‐NMR, 13 C‐NMR, HRMS. All the synthesized compounds were evaluated for their anti‐bacterial and anti‐fungal activities. The anti‐bacterial activities results reveal that the compounds 4a , 4g , 4i , and 4j are most active against S. aureus . In the case of B. subtilis the compounds 4a , 4i , and 4j are found to be most active. The compounds 4c , 4e , 4i , and 4j are most active against E. coli . In the case of P. aeruginosa 4a , 4i & 4j are found to be more active. On the other hand, the anti‐fungal activity result shows that the compounds 4d , 4f , 4i , and 4j are more active against A. niger . The compounds 4a , 4d , 4i , and 4j are found to be more active against C. albicans .