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Organocatalyzed Kabbe condensation reaction for mild and expeditious synthesis of 2,2‐dialkyl and 2‐spiro‐4‐chromanones
Author(s) -
Kapuriya Naval P.,
Bhalodia Jasmin J.,
Ambasana Mrunal A.,
Patel Rashmi B.,
Bapodra Atul H.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4054
Subject(s) - chemistry , bifunctional , pyrrolidine , condensation , organic chemistry , condensation reaction , organocatalysis , reaction conditions , catalysis , combinatorial chemistry , enantioselective synthesis , physics , thermodynamics
An expeditious Kabbe condensation reaction for the synthesis of 2,2‐dialkyl and 2‐spiro‐chroman‐4(1 H )‐ones has been developed using pyrrolidine‐butanoic acid in DMSO as bifunctional organocatalyst. Unlike existing methods, this reaction proceeds at room temperature with high yields, rendering it an attractive method to synthesize a vast variety of privileged 4‐chromones.