Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents | Zendy

Haoran Wang | Zendy; Akhtar Wasim | Zendy; Nainwal Lalit Mohan | Zendy; Kaushik Sumit Kumar | Zendy; Akhter Mymoona | Zendy; Shaquiquzzaman Mohammad | Zendy; Alam Mohammad Mumtaz | Zendy

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Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents

Author(s) -

Haoran Wang,

Akhtar Wasim,

Nainwal Lalit Mohan,

Kaushik Sumit Kumar,

Akhter Mymoona,

Shaquiquzzaman Mohammad,

Alam Mohammad Mumtaz

Publication year - 2020

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.4052

Subject(s) - benzimidazole , chemistry , cancer cell lines , cytotoxicity , elemental analysis , combinatorial chemistry , proton nmr , stereochemistry , cancer cell , organic chemistry , cancer , biochemistry , in vitro , medicine

Thirteen new benzimidazole pendant cyanopyrimidine derivatives were synthesized. The compounds were synthesized through multistep reaction protocol. The structures of synthesized derivatives were studied by EI‐MS, 1 H NMR, FT‐IR and elemental analysis. All the compounds were studied for their anticancer activity at National Cancer Institute. Except compound 7j , all the compounds unveiled cytotoxicity against cancer cells. The most active compound 7a had shown highest value of growth inhibition of 88.44% and 84.19% against HOP‐92 and T‐47D cancer cell lines.

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