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Synthesis and biological evaluation of benzimidazole pendant cyanopyrimidine derivatives as anticancer agents
Author(s) -
Haoran Wang,
Akhtar Wasim,
Nainwal Lalit Mohan,
Kaushik Sumit Kumar,
Akhter Mymoona,
Shaquiquzzaman Mohammad,
Alam Mohammad Mumtaz
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4052
Subject(s) - benzimidazole , chemistry , cancer cell lines , cytotoxicity , elemental analysis , combinatorial chemistry , proton nmr , stereochemistry , cancer cell , organic chemistry , cancer , biochemistry , in vitro , medicine
Abstract Thirteen new benzimidazole pendant cyanopyrimidine derivatives were synthesized. The compounds were synthesized through multistep reaction protocol. The structures of synthesized derivatives were studied by EI‐MS, 1 H NMR, FT‐IR and elemental analysis. All the compounds were studied for their anticancer activity at National Cancer Institute. Except compound 7j , all the compounds unveiled cytotoxicity against cancer cells. The most active compound 7a had shown highest value of growth inhibition of 88.44% and 84.19% against HOP‐92 and T‐47D cancer cell lines.