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Trifluoroborane catalyzed chemoselective synthesis of highly functionalized 1,3‐thiazin‐2‐ylidenes
Author(s) -
Luo Zhibin,
Bhavanarushi Sangepu,
Sreenivas Avula,
Reddy Narra Srikanth,
Valeru Anil,
Khan Imran,
Xu Yin,
Liu Bin,
Xie Jimin
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4049
Subject(s) - chemistry , thiazine , catalysis , thioacetamide , propargyl , broad spectrum , lewis acids and bases , combinatorial chemistry , organic chemistry , medicinal chemistry , biochemistry
An efficient chemoselective synthesis of 1,3‐thiazine‐2‐ylidenes was achieved via annulations of β ‐aroyl‐thioacetamide with propargyl alcohols using BF 3 OEt 2 as Lewis acid catalyst. A broad spectrum of substrates was well tolerated under the mild reaction conditions producing desired thiazine heterocyclics in good yields.