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Synthesis of substituted pyrimidine using ZnFe 2 O 4 nanocatalyst via one pot multi‐component reaction ultrasonic irradiation
Author(s) -
Chavan Pravin,
Bangale Sachin,
Pansare Dattatraya,
Shelke Rohini,
Jadhav Shivaji,
Tupare Shrikrushna,
Kamble Dhanraj,
Rai Megha
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4048
Subject(s) - chemistry , malononitrile , aldehyde , yield (engineering) , benzimidazole , pyrimidine , catalysis , one pot synthesis , combinatorial chemistry , environmentally friendly , reaction conditions , component (thermodynamics) , organic chemistry , stereochemistry , ecology , materials science , thermodynamics , physics , metallurgy , biology
A highly efficient, eco‐friendly, recyclable heterogeneous ZnFe 2 O 4 nanocatalyzed synthesis of 2‐amino‐4‐substituted 1,4‐dihydrobenzo[4,5]imidazo[1,2‐a]pyrimidine‐3‐carbonitrile (4a‐j) derivatives via one pot multicomponent reaction of benzimidazole ( 1 ), substituted aromatic aldehyde ( 2a‐j ) and malononitrile ( 3 ) under ultrasonic irradiations. Significance of this synthetic approach is short reaction time, easy handling, simplicity, efficiency, high yield, and recoverable catalyst.