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Three‐component reaction for synthesis of 2‐amino ‐6‐aryl‐5‐(phenylamino)‐3, 7‐dihydro‐4 H ‐pyrrolo[2,3‐ d ]pyrimidin‐4‐one derivatives in water
Author(s) -
Yang Xiaopeng,
Li Chunmei,
Qi Chenze,
Zhang Furen
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4042
Subject(s) - chemistry , aniline , catalysis , aqueous medium , aryl , acetic acid , domino , cascade reaction , combinatorial chemistry , component (thermodynamics) , reaction conditions , aqueous solution , organic chemistry , alkyl , physics , thermodynamics
A new three‐component domino reaction for the synthesis of 2‐amino‐6‐aryl‐5‐(phenylamino)‐3,7‐dihydro‐4 H ‐pyrrolo[2,3‐ d ]pyrimidin‐4‐one derivatives 4 using acetic acid as catalyst has been established. The reaction was performed in aqueous media using readily available and inexpensive 2,6‐diaminopyrimidin‐4(3 H )‐one 1 , 2,2‐dihydroxy‐1‐arylethan‐1‐one 2 and aniline 3 as substrates. The simple and efficient one‐pot three‐component approach, inexpensive catalyst, green reaction media, make the present methodology a good synthetic procedure.