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An efficient and highly selective method for the synthesis of cryptotackiene derivatives catalyzed by iodine
Author(s) -
Wang XiangShan,
Zhou Jie,
Yin MingYue,
Yang Ke,
Tu ShuJiang
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.404
Subject(s) - chemistry , iodine , catalysis , selectivity , pyran , organic chemistry , combinatorial chemistry , medicinal chemistry
A mild, efficient and highly selective approach to the synthesis of cryptotackiene derivatives via three‐component reactions of 3‐amino‐9‐ethylcarbazole and aromatic aldehydes with electron‐rich alkenes, such as 2,3‐dihydrofuran, or 3,4‐dihydro‐2 H ‐pyran catalyzed by iodine in THF is reported. It is worth to note that only trans ‐products were obtained with high selectivity in good to high yields, which confirmed by X‐ray diffraction analysis. J. Heterocyclic Chem., (2010).