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Microwave assisted synthesis and antimicrobial evaluation of novel substituted thiosemicarbazide derivatives of pyrimidine
Author(s) -
Panneerselvam Theivendren,
Mandhadi Jithendar Reddy
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4013
Subject(s) - chemistry , antimicrobial , micrococcus luteus , bacillus cereus , aspergillus niger , pyrimidine , antibacterial activity , klebsiella pneumonia , staphylococcus aureus , staphylococcus epidermidis , pseudomonas aeruginosa , escherichia coli , combinatorial chemistry , organic chemistry , stereochemistry , bacteria , biochemistry , genetics , biology , gene
A new series of antimicrobial thiosemicarbazide substituted pyrimidine derivatives were synthesized by using thiosemicarbazide and ethyl 2‐((2‐amino‐5‐carbamoyl‐6‐[substituted benzyl] pyrimidin‐4‐yl)oxy)acetate derivatives and subsequent addition of acetaldehyde and acetone. The designed compounds were screened for Antibacterial activity against Staphylococcus aureus , Staphylococcus epidermidis , Micrococcus luteus , Bacillus cereus , Escherichia coli , Pseudomonas aeruginosa , and Klebsiella pneumonia in comparison with the standard drugs Ciprofloxacin and antifungal effect against Aspergillus niger and Aspergillus fumigates in comparison with the standard drug Ketoconazole reveal the potency of synthesized derivatives. In accordance with the data obtained from antimicrobial activity, all the synthesized derivatives have shown good activity against the tested microbes. Among them, compound bearing 2‐hydroxy and 3‐chloro derivatives of thiosemicarbazide substituted pyrimidine has shown good activity against all the tested organisms.