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Catalyst‐free one‐pot synthesis of a new class of 2 H ‐furo[3,2‐ c ]chromene‐2,4( 3 H )‐dione and arylamino‐bis(coumarin)methane derivatives on water
Author(s) -
Olyaei Abolfazl,
Moghadam Hajar Ramezanipour,
Sadeghpour Mahdieh
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.4007
Subject(s) - chemistry , catalysis , coumarin , condensation , environmentally friendly , condensation reaction , methylene , solvent , organic chemistry , combinatorial chemistry , ecology , physics , biology , thermodynamics
A catalyst‐free, environmentally benign, and simple procedure has been developed for the efficient synthesis of novel 2 H ‐furo[3,2‐ c ]chromene‐2,4(3 H )‐dione and 3,3′‐((arylamino)methylene)bis(4‐hydroxycoumarin) derivatives from one‐pot three‐component condensation of 4‐hydroxycoumarin, glyoxalic acid monohydrate and various amines in water under reflux condition. In this green synthetic protocol, the solvent water itself catalyzed the reaction via hydrogen bonding. One‐pot, high yields, short reaction times, simple operation, environmental friendly and easy workup procedure are highlights. This is the first report for the synthesis of 2 H ‐furo[3,2‐ c ]chromene‐2,4(3 H )‐dione and arylamino‐bis(coumarin)methane derivatives.