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A facile one‐step synthesis of chromeno[4,3‐ b ]pyridine derivatives promoted by niobium pentachloride
Author(s) -
Oshiro Paula B.,
Bregadiolli Bruna A.,
SilvaFilho Luiz C.
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3988
Subject(s) - chemistry , benzaldehyde , pyridine , niobium , phosphorus pentachloride , organic chemistry , combinatorial chemistry , one step , reaction conditions , catalysis , art , visual arts
Chromenes are part of an important class of heterocyclic compounds, natural or synthetic, and have many biological and chemical applications. Among them, chromenopyridines has arisen as a promising material for pharmacological applications. In this work is described a simple and cost‐effective method to synthesize chromeno[4,3‐ b ]pyridine derivatives from multicomponent reaction between 4‐aminocoumarin, benzaldehyde derivatives, and ethyl benzoylacetates catalyzed by niobium pentachloride. The new method provides good yields with reasonable reaction times, under mild reaction conditions.