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Aqueous‐Mediated green synthesis of novel spiro[indole‐quinazoline] derivatives using kit‐6 mesoporous silica coated Fe 3 O 4 nanoparticles as catalyst
Author(s) -
Abdolmohammadi Shahrzad,
Shariati Shahab,
Fard Narges Elmi,
Samani Amir
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3981
Subject(s) - chemistry , catalysis , mesoporous material , mesoporous silica , aqueous solution , indole test , nanoparticle , guanidine , aqueous medium , green chemistry , combinatorial chemistry , organic chemistry , nuclear chemistry , chemical engineering , reaction mechanism , engineering
In this work, a series of eight new spiro[3,4′]1,3‐dihydro‐2 H ‐indol‐2‐one‐2′‐amino‐4′,6′,7′,8′‐tetrahydro‐2′,5’(1’ H ,3’ H )‐quinazoline‐diones were successfully synthesized through a three‐component reaction of 1 H ‐indole‐2,3‐diones (isatins), guanidine nitrate, and 1,3‐cyclohexanediones, by use of Kit‐6 mesoporous silica coated Fe 3 O 4 nanoparticles (Fe 3 O 4 @SiO 2 @KIT‐6) as a highly efficient magnetically separable nanocatalyst in aqueous media at 60°C. Several notable features of thiseco‐friendly protocol are high yields of products, short reaction times, operational simplicity, and the use of easily available and recyclable catalyst.