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Synthesis of novel isoxazole functionalized pyrazolo[3,4‐ b ]pyridine derivatives; their anticancer activity
Author(s) -
Ravula Sampath,
Bobbala Ramana Reddy,
Kolli Balakrishna
Publication year - 2020
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3968
Subject(s) - chemistry , isoxazole , hela , pyridine , sodium hypochlorite , amine gas treating , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , cell , biochemistry
A series of novel isoxazole functionalized pyrazolo[3,4‐b]pyridine derivatives 5a‐n were prepared, respectively, initiated from 6‐thiophenyl‐4‐(trifluoromethyl)‐1 H ‐pyrazolo[3,4‐ b ]pyridin‐3‐amine 3 through selective N ‐propargylation, and these N ‐propargylated compounds 4 were cyclized with aryloximes by using of sodium hypochlorite, and obtained the title products 5a‐n . All the final products 5a‐n were submitted for anticancer activity against four cancer cell lines such as “HeLa—cervical cancer (CCL‐2); COLO 205—colon cancer (CCL‐222); HepG2—liver cancer (HB‐8065); MCF7—breast cancer (HTB‐22)”; Compounds 5c , 5d , and 5h are found to have more prominent anticancer activity at micro molar concentration.